Fucking brilliant trailer, as I said in the E3 thread I actually shouted yes at the top of my voice when I first watched it. So many things to talk about:
The guy speaking at the start is Skullface but the words he is saying are describing Grey Fox, could be something there.
0:32 in the trailer I swear that's David Hayter ("I changed too"), probably not though.
Zero's new voice actor is actually good.
Kaz is now apparently blind, that doesn't go along with the MGS1 story though as Kaz (Master Miller) trained Solid Snake, not sure how you train someone if you're blind but this is Metal Gear so.
Reference to Lord of the Flies at 3:21 with the pig head and Liquid.
Paz is still alive even though she blew into pieces at the end of Ground Zeroes, either that or she is a clone or Big Boss is imagining her, which takes me onto my next point.
Big Boss is going mental, 4:33 in the trailer is either Big Boss imagining Skullface or camera trickery but I think Skullface might die at some point in the game and Big Boss is imagining him. You also have the spikes coming out of the ground.
And the big one at the end of the trailer, the second kid is either Solid Snake or Solidus although Solidus was cloned later but had more sever accelerated aging. I think it's Solid Snake tbf.